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Significant conservation in cognitive and neurodevelopmental mechanisms exist between Drosophila and mammals. In addition, while mechanisms of aging are relatively well conserved, Drosophila age much faster than mammals. Thus Drosophila are an ideal organism in which to study cognitive and neurodegenerative diseases.
Animal models of neurodegenerative diseases
Powerful genetic techniques exist that allow genes to be disrupted and overexpressed easily. Phenotypes observed from these mutants can then be used to screen for genetic modifiers to elucidate pathways involved in disease pathology.
Unable to display preview. Download preview PDF. Skip to main content. Advertisement Hide. Modeling Cognitive and Neurodegenerative Disorders in Drosophila melanogaster. This is a preview of subscription content, log in to check access. Deconstructing memory in Drosophila. Curr Biol ;R— CrossRef Google Scholar. Unconventional sex: Fresh approaches to courtship learning. Curr Opin Neurobiol ;— Tully T, et al. A return to genetic dissection of memory in Drosophila.
PubMed Google Scholar. Genetic dissection of consolidated memory in Drosophila. Cell ;— Yin JC, Tully T. CREB and the formation of long-term memory.
Liebl FL, et al. Genome-wide P-element screen for Drosophila synaptogenesis mutants. J Neurobiol ;— Vijayakrishnan N, Broadie K. Temperature-sensitive paralytic mutants: Insights into the synaptic vesicle cycle. Biochem Soc Trans ;— Huang FD, et al. Rolling blackout is required for synaptic vesicle exocytosis.
J Neurosci ;— Kidokoro Y. Neurosignals ;— Zhang YQ, et al. Tong J, et al. Neurofibromin regulates G protein-stimulated adenylyl cyclase activity. Nat Neurosci ;— Pan L, et al. The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr Biol ; — The endocrine regulation of aging by insulin-like signals.
Science ;— Horiuchi J, Saitoe M.
Can flies shed light on our own age-related memory impairment? Ageing Res Rev ;— Flies and their golden apples: The effect of dietary restriction on Drosophila aging and age-dependent gene expression. Evolutionary medicine: From dwarf model systems to healthy centenarians? Fortini ME, et al. A survey of human disease gene counterparts in the Drosophila genome. J Cell Biol ;F23— Brand AH, Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
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Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch. Osterwalder T, et al. A conditional tissue-specific transgene expression system using inducible GAL4. Rorth P, et al. Systematic gain-of-function genetics in Drosophila. P element insertion-dependent gene activation in the Drosophila eye. Techniques: Fruit flies as models for neuropharmacological research. Trends Pharmacol Sci ;— Xu GF, et al.
The neurofibromatosis type 1 gene encodes a protein related to GAP. The I, et al. Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Neurofibromatosis type 1: New insights into neurocognitive issues. Curr Neurol Neurosci Rep ;— Zhong Y. Nature ;— Guo HF, et al.
Developmental Neuroscience Group - University of Birmingham
A neurofibromatosisregulated pathway is required for learning in Drosophila. Fieber LA. Ionic currents in normal and neurofibromatosis type 1-affected human Schwann cells: Induction of tumor cell K current in normal Schwann cells by cyclic AMP. J Neurosci Res ;— The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclaseactivating polypeptide-mediated signaling in astrocytes. Zarnescu DC, et al.
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Genes Brain Behav ;— Abnormal development of dendritic spines in FMR1 knock-out mice. Grossman AW, et al. Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond. All Pages Books Journals. View on ScienceDirect. Serial Volume Editors: Nigel Atkinson. Hardcover ISBN: Imprint: Academic Press. Published Date: 23rd September Page Count: View all volumes in this series: International Review of Neurobiology.
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Free Shipping Free global shipping No minimum order. Introduction II. The Synaptic Connection V. Adaptations to Electrophysiology IV. Related Behavioral Measures V. The Behavior III. Motivation II. Physiology in Behaving Flies IV. Results III. Closing Remarks Acknowledgments.
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